In terms of inconsistent conclusions across all relevant randomized controlled trials (RCTs) and available meta-analyses, we aimed to use a meta-analysis and trial sequential analysis (TSA) to ...

The clinical utility of genotype-guided (pharmacogenetically based) dosing of warfarin has been tested only in small clinical trials or observational studies, with equivocal results. We randomly ...

For the majority of common human diseases, only a small fraction of the heritability can be attributed to known genetic variation. A widely held hypothesis is that the remaining heritability can be ...