Nov 2, 2023 · The mesolimbic pathway involves cross-talk between the ventromedial striatum and the nucleus accumbens (NAcc). The mesolimibc pathway is responsible for the binge stage's reward and …

Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by a combination of exaggerated incentive salience and habit formation, reward deficits and stress …

Dec 16, 2022 · In this review, we highlight the neurobiological mechanisms of these three stages of addiction. The abnormal activity of the ventral tegmental, nucleus accumbens, and caudate nucleus …

Apr 1, 2021 · In this article, we discuss the changing definitions and clinical criteria that describe and classify addictive disorders. Using examples from functional neuroimaging studies we summarise the …

Jan 15, 2019 · Advances in neuroscience and addiction research have helped to describe the neurobiological changes that occur when a person transitions from recreational substance use to a …

Aug 5, 2025 · Addiction touches millions of lives, yet it’s often misunderstood as a personal weakness or moral failing. In reality, addiction is rooted in the ancient architecture of the human brain.

Jan 28, 2016 · Here we review recent advances in the neurobiology of addiction to clarify the link between addiction and brain function and to broaden the understanding of addiction as a brain disease.

Aug 12, 2021 · In technical terms, drug addiction is defined as a chronic, relapsing disease resulting from sustained effects of drugs on the brain.

Addiction involves neuroadaptations in key brain circuits, notably the mesolimbic dopamine pathway, which includes the ventral tegmental area and nucleus accumbens.

Neuroscience research has revealed that addiction is a chronic, relapsing disease of the brain triggered by repeated exposure to drugs in those who are vulnerable because of genetics and developmental …